1-Cbz-3-amino piperidine
1-N-Cbz-3-aminopiperidine
CAS: 711002-74-3
Molecular Formula: C13H18N2O2
1-Cbz-3-amino piperidine - Names and Identifiers
| Name | 1-N-Cbz-3-aminopiperidine |
| Synonyms | 1-Cbz-3-amino piperidine 1-N-Cbz-3-aminopiperidine 1-N-CBZ-3-AMINOPIPERIDINE 3-AMINO-1-N-CBZ-PIPERIDINE DL-3-AMINO-1-N-CBZ-PIPERIDINE 3-AMINOPIPERIDINE, N1-CBZ PROTECTED 3-Amino-1-benzyloxycarbonylpiperidine Benzyl 3-aminopiperidine-1-carboxylate 3-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 3-Amino-piperidine-1-carboxylic acid benzyl ester |
| CAS | 711002-74-3 |
| InChI | InChI=1/C13H18N2O2/c14-12-7-4-8-15(9-12)13(16)17-10-11-5-2-1-3-6-11/h1-3,5-6,12H,4,7-10,14H2 |
1-Cbz-3-amino piperidine - Physico-chemical Properties
| Molecular Formula | C13H18N2O2 |
| Molar Mass | 234.29 |
| Density | 1.151±0.06 g/cm3(Predicted) |
| Melting Point | 168-170°C |
| Boling Point | 367.2±42.0 °C(Predicted) |
| Flash Point | 175.9°C |
| Vapor Presure | 1.38E-05mmHg at 25°C |
| pKa | 10.33±0.20(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.558 |
1-Cbz-3-amino piperidine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN1760 |
| HS Code | 29333990 |
1-Cbz-3-amino piperidine - Introduction
1-N-Cbz-3-aminopiperidine(1-N-Cbz-3-aminopiperidine) is an organic compound, which is substituted with one amino and one benzyloxycarbonyl (Cbz) group on the piperidine nucleus. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: Colorless crystalline solid
-Molecular formula: C14H18N2O
-Molecular weight: 230.31g/mol
-melting point: 68-71 ℃
-Solubility: Soluble in organic solvents such as ethanol and dimethylformamide
Use:
1-N-Cbz-3-aminopiperidine is commonly used as an intermediate in organic synthesis and has the following applications:
-For the preparation of drugs and biologically active substances
-for the synthesis of biologically active compounds
-Can be used as a synthetic raw material for antiarrhythmic drugs
Preparation Method:
The preparation method of 1-N-Cbz-3-aminopiperidine generally involves the following steps:
1. First, piperidine is reacted with an amination reagent (such as acetone oxime or isocyanate) to generate an amino derivative of piperidine.
2. The amino derivative of piperidine is then reacted with benzyl bicarbonate (CbzH) to produce 1-N-Cbz-3-aminopiperidine.
Safety Information:
The relevant safety information of 1-N-Cbz-3-aminopiperidine is limited, so care should be taken when handling and operating.
-May cause irritation to eyes, skin and respiratory tract, so contact should be avoided.
-Wear appropriate protective equipment, such as laboratory gloves and goggles, to ensure good indoor ventilation.
-Should be stored in a dry and cool place, and away from combustibles and oxidants.
Nature:
-Appearance: Colorless crystalline solid
-Molecular formula: C14H18N2O
-Molecular weight: 230.31g/mol
-melting point: 68-71 ℃
-Solubility: Soluble in organic solvents such as ethanol and dimethylformamide
Use:
1-N-Cbz-3-aminopiperidine is commonly used as an intermediate in organic synthesis and has the following applications:
-For the preparation of drugs and biologically active substances
-for the synthesis of biologically active compounds
-Can be used as a synthetic raw material for antiarrhythmic drugs
Preparation Method:
The preparation method of 1-N-Cbz-3-aminopiperidine generally involves the following steps:
1. First, piperidine is reacted with an amination reagent (such as acetone oxime or isocyanate) to generate an amino derivative of piperidine.
2. The amino derivative of piperidine is then reacted with benzyl bicarbonate (CbzH) to produce 1-N-Cbz-3-aminopiperidine.
Safety Information:
The relevant safety information of 1-N-Cbz-3-aminopiperidine is limited, so care should be taken when handling and operating.
-May cause irritation to eyes, skin and respiratory tract, so contact should be avoided.
-Wear appropriate protective equipment, such as laboratory gloves and goggles, to ensure good indoor ventilation.
-Should be stored in a dry and cool place, and away from combustibles and oxidants.
Last Update：2024-04-09 20:49:11
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Product Name: 1-N-Cbz-3-aminopiperidine Visit Supplier Webpage Request for quotationCAS: 711002-74-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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